e.   Scientific Research (Secondary)

The Biological Activities of Selected Compounds, their Targeted Industries & the Scientific Support

(Complete papers or additional research studies are available upon request)

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Antibacterial & Antifungal Properties
For use in: Cosmetics, Oral Hygiene, Food & Agriculture, Timber

Morita, Y., Matsumura, E., Okabe, T., Shibata, M., Sugiura, M., Ohe, T., Tsujibo, H., Ishida, N., Inamori, Y.   (2003)   Biological activity of tropolone.   Biological & Pharmaceutical Bulletin.  Vol. 26(10): 1487-1490.

Arima, Y., Nakai, Y., Hayakawa, R., Nishino, T.   (2003)   Antibacterial effect of β-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis.   Journal of Antimicrobial Chemotherapy.  Vol. 51(1): 113-122.

Baya, M., Soulounganga, P., Gelhaye, E., Gerardin, P.   (2001)   Fungicidal activity of β-thujaplicin analogues.   Pest Management Science  Vol. 57: 833-838.

Osawa, K., Matsumoto, T., Maruyama, T., Takiguchi, T., Okuda, K., Takazoe, I.   (1990)   Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria.   Bulletin Tokyo Dental College  Vol. 31(1): 17-21.

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Antioxidant Properties
For use in: Skin care products, Pharmaceutical

Baba, T., Nakano, H., Tamai, K., Sawamura, D., Hanada, K., Hashimoto, I., Arima, Y.   (1998)   Inhibitory effect of β-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes.   Journal of Investigative Dermatology.  Vol. 110(1): 24-28.

Arima, Y., Hatanaka, A., Tsukihara, S., Fujimoto, K., Fukuda, K., Sakurai, H.   (1997)   Scavenging activities of α-, β- and γ-thujaplicins against active oxygen species.   Chemical & Pharmaceutical Bulletin.  Vol. 45(12): 1881-1886.

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Anti-inflammatory & Enzyme Inhibitor Properties
For use in: Cosmetics, Pharmaceuticals

Morita, Y., Matsumura, E., Okabe, T., Shibata, M., Sugiura, M., Ohe, T., Tsujibo, H., Ishida, N., Inamori, Y.  (2003)   Biological activity of tropolone.   Biological & Pharmaceutical Bulletin.  Vol. 26(10): 1487-1490.

Morita, Y., Matsumura, E., Tsujibo, H., Yasuda, M., Okabe, T., Sakagami, Y., Kumeda, Y., Ishida, N., Inamori, Y. (2002)   Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata.   Biological & Pharmaceutical Bulletin.  Vol. 25(8): 981-985.

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Phytogrowth Inhibitory Properties
For use in: Food & Agricultural Products

Morita, Y., Matsumura, E., Tsujibo, H., Yasuda, M., Sakagami, Y., Okabe, T., Ishida, N., Inamori, Y.  (2001)   Biological activity of α-thujaplicin, the minor component of Thujopsis dolabrata.   Biological & Pharmaceutical Bulletin.  Vol. 24(6): 607-611.

Sakagami, Y., Inamori, Y., Isoyama, N., Tsujibo, H., Okabe, T., Morita, Y., Ishida, N.   (2000)   Phytogrowth-inhibitory activities of β-Dolabrin & γ-Thujaplicin, hinokitiol-related compounds and constituents or Thujopsis dolabrata.   Biological & Pharmaceutical Bulletin.  Vol. 23(5): 645-648.

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Pesticidal & Pest Repellent Properties
For use in: Household Products & Agricultural Products

Inamori, Y., Sakagami, Y., Morita, Y., Shibata, M., Sugiura, M., Kumeda, Y., Okabe, T., Tsujibo, H., Ishida, N. (2000)   Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities.   Biological & Pharmaceutical Bulletin.  Vol. 23(8): 995-997.

Hach, V., McDonald, E. C.   (1973)   Terpenes & Terpenoids IV: Esters & Amides of Thujic Acid.   Canadian Journal of Chemistry.  Vol. 51: 3230-3235.

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Anti-Cancer Properties
For use in: Pharmaceuticals

Matsumura, E., Morita, Y., Date, T., Tsujibo, H., Yasuda, M., Okabe, T., Ishida, N., Inamori, Y. (2001)   Cytotoxicity of the hinokitiol-related compounds, γ-thujaplicin & β-dolabrin.   Biological & Pharmaceutical Bulletin.  Vol. 24(3): 299-302.

Tanaka, T., Muto, N., Itoh, N., Dota, A., Nishina, Y, Inada, A., Tanaka, K.   (1995)   Hinokitiol induces differentiation of teratocarcinoma F9 cells.   Biological & Pharmaceutical Bulletin.  Vol. 18(11): 1576-1579.